Precise Glycan Editing
We develop spatiotemporally resolved, substrate-selective editing tools and interface-level interventions along both protein-glycan and RNA-glycan axes to enable precise glycan control in defined biological contexts.
Research overview
Chemical biology of glycans: from reading and editing to engineering.
We focus on the chemical biology of functional assemblies. Our work follows a "read–edit–engineer" framework along two axes — glycans on proteins and glycans on RNA — and turns mechanistic understanding into controllable cellular programmes and disease interventions.
Research directions
One framework, three threads
The glycome underpins molecular interaction and information flow in living systems. Along the protein- and RNA-glycan axes, we ask three questions in sequence: can we edit glycans precisely? how do their functions unfold? and can we convert that knowledge into diagnostics and therapeutics?
Functional Decoding
Using interdisciplinary chemical-biology tools, we dissect functional interactions between glycans and proteins/RNA in defined spatial and state contexts — from biomolecular condensates to the plasma membrane — and study how glycans shape transcription, translation, and other fundamental cellular processes.
Translational Applications
We map functional microenvironments co-assembled by glycans and other macromolecules, and design systematic profiling and intervention strategies for disease diagnosis and therapy — from glycan-editing-enhanced tumour immunity to new cell-surface markers, glycan-mediated interactions, and glycan-enabled biologics.
Publications
The full record is on Google Scholar.
Every paper, preprint, and citation count, kept up to date.